A positive diagnosis of CD can be achieved through a combination of clinical parameters, immunological parameters (positive serological levels for total IgA and IgA anti-intestinal transglutaminase 2 antibodies (TGA-IgA), IgA anti-endomysium antibodies (EMA-IgA) and IgG deamidated gliadin peptide (DGP) antibodies (DGP-IgG) and/or histological data, obtained by biopsy; in clinical practice, the serologic IgA tissue transglutaminase antibodies have a sensitivity close to 97%, while EMA-IgA antibodies are highly specific markers (approximately 100%) for CD diagnosis [67,68,69,70,71,72,73]. This evidence concerns the gene TGM2 and Cowden disease.