The molecular mechanisms of COVID-19 appear to have delayed IFN responses, which are responsible for the high secretion of IL-6, IL-7 and TNF-α, hyperinflammation and worsening of clinical status, with the release of the following autoantibodies to dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2), and to the casein kinase family (Casein kinase 1, alpha 1 (CSNK1A1), Casein kinase 2, alpha 1 (CSNK2A1) and Casein kinase 1, epsilon 1 (CSNK1E1)), found exclusively in MIS-C [120]. Here, MAP2K2 is linked to COVID-19.