Likewise, an overexpression of COX-2 and P-gp has been demonstrated in resistant K562 cells, with a decrease in apoptosis involving the Akt/p-Akt signaling pathway, which suggests the participation of COX-2 and P-gp in the development of resistance of CML cells [45]. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.