D-AKAP2 knockout in cardiomyocytes of adult mice increases infarct size and accelerates HF induced by MI, as shown by LV enlargement and reduced function [29], since, in cardiomyocytes, D-AKAP2 promotes PKA-mediated activation of the steroid receptor co-activator 3 (Src3) and estrogen receptor α (ERα). The gene discussed is ESR1; the disease is myocardial infarction.