For the first time, we have provided evidence that iRhom2 is essential for regulating the progression of liver fibrosis and injuries caused by alcohol exposure, which is most likely to be achieved by activating the TACE/TNFR/NF-κB and JNK/Nrf2/HO-1 signaling pathways (Figure 7). Here, RHBDF2 is linked to Hepatic fibrosis.