CA inhibitors can be used for the development of anti-infective agents (CAs are responsible for the survival and virulence of certain pathogens) [38], for the treatment of glaucoma [39], cerebral ischemia [40], rheumatoid arthritis [41], obesity [42], neuropathic pain [43], epilepsy [44], or cancer [45]; in this context, it is important to highlight that CA IX and XII are overexpressed in numerous tumors, where they control the microenvironment pH (acidification of the extracellular medium) [46] and certain metabolic processes connected to tumor growth and metastasis [47]. Here, CA9 is linked to neoplasm.