TREM2 and Alzheimer disease: Thus, we confirmed its expression in the entorhinal cortex and observed that it was upregulated in AD samples (FC = 2.02, p-value < 0.05), being the second transcript of TREM2 most expressed; however, after adjusting for age and gender, the difference between AD samples and controls was no longer statistically significant (FC = 1.28, p-value = 0.50) (Figure 3B,C).