The enhanced effect observed in both CRC cell lines following combined AdoMet/miRNAs treatment clearly indicated that AdoMet-dependent upregulation of miR-34a, miR-34c, and miR-449a is involved in the AdoMet-induced transition from N- to E-cadherin expression, in turn, responsible for the suppression of cell migration. This evidence concerns the gene CDH1 and colorectal carcinoma.