We found that AdoMet and miR-34a, miR-34c, and miR-449a individually reduced the expression of MMP-2 and MMP-9 in HCT-116 (Figure 3A) and Caco-2 (Figure 3B) cells as compared to control and that their combined treatment was more effective than single treatment indicating a functional relationship between AdoMet and these miRNAs and suggesting that the antimigratory properties of AdoMet in CRC cells are mediated by the upregulation of tumor suppressors miR-34a, miR-34c, and miR-449a. The gene discussed is MMP2; the disease is colorectal carcinoma.