In the current study we demonstrated for the first time that the expression of TRIM67 was downregulated in HFD-fed WT mice as compared to the CTR diet group of WT mice.I It has been noted in previous studies that overexpression of TRIM proteins can increase the membrane repair capacity in muscular dystrophy and restore muscle function and morphology [27,28]. Here, TRIM67 is linked to muscular dystrophy.