JAK2 and laryngeal squamous cell carcinoma: In addition, curcumin has also been shown to inhibit VM in squamous cell carcinoma of the larynx through the inhibition of the Janus kinase-2 (JAK-2)/signal transducer activator of transcription protein (STAT) signaling pathway, and the downregulation of MMP-2 and VEGF expression [13].