The most common partners involved in TFE3-tRCC are PRCC (papillary renal cell carcinoma) with t(X;1)(p11.2;q21.2), ASPSCR1(ASPL) (alveolar soft part sarcoma locus) with the t(X;17)(p11.2;q25) and SFPQ (splicing factor proline- and glutamine-rich protein) with t(X;1)(p11.2;p34) [7,20,31]. This evidence concerns the gene ASPSCR1 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.