Immunohistochemical analysis using the recommended minimum antibody panel (CAIX, TFE3, PAX8, HMB-45 and Melan-A, Cathepsin K, AMACR, CK-7, EMA) could be advised routinely for every case of RCC, regardless of the patient′s age and the microscopic features of the tumor. This evidence concerns the gene TFE3 and renal cell carcinoma.