However, transcriptomic profiles were heterogeneous among 54 cases studied with TFE3 that allowed the identification and characterization of five molecular subtypes of TFE3-tRCC with distinct representative genes involving stroma, angiogenesis, proliferation and KRAS down [20]. Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.