Immunohistochemical analysis using the recommended minimum antibody panel (CAIX, TFE3, PAX8, HMB-45 and Melan-A, Cathepsin K, AMACR, CK-7, EMA) could be advised routinely for every case of RCC, regardless of the patient′s age and the microscopic features of the tumor. The gene discussed is MLANA; the disease is renal cell carcinoma.