TFE3 and neoplasm: Compared to all tumor types, ASPSCR1-TFE3, NONO-TFE3, PRCC-TFE3 and SFPQ-TFE3 signatures are characterized by the overexpression of genes implicated in mTORC1 signaling, the antioxidant stress response, ROS sensing and the response to oxidative stress and xenobiotics including activation of the NRF2 pathway [7].