Both TFE3 and TFEB tRCCs may overlap with each other’s and with other RCCs’ morphologies, in particular with clear cell RCC, papillary RCC or, more rarely, clear cell papillary renal cell carcinomas as well as perivascular epithelioid cell tumors (PEComas). Here, TFEB is linked to neoplasm with perivascular epithelioid cell differentiation.