CD8 + T cell, T cell and macrophage signatures were also lower relative to ccRCC, which was also demonstrated by immunohistochemistry (low CD8 + T cell infiltrations, immunohistochemistry confirmed in two-thirds (74.6%, 47/63) of tRCC) [20]. This evidence concerns the gene CD8A and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.