Chlorogenic acid could exert anti-diabetic and anti-obesity effects through the AMPK pathway, enhance the expression levels of PPARγ, PRDM16, and PGC-1α in BATs and WATs, increase the insulin production, and inhibit key enzymes in lipid biosynthesis [124]. The gene discussed is PPARGC1A; the disease is obesity due to melanocortin 4 receptor deficiency.