Another possibility for BMME targeting therapy resistance might be caused by the cross-talk of BMME and MM cells via soluble factors such as IL-6, APRIL, and growth factors, but most importantly via the integrin-mediated cell adhesion and Notch signaling resulting in inhibition of apoptosis [118,119,120,121], on which the major cytotoxic machinery of the immune cells significantly depends [122,123,124,125]. Here, TNFSF13 is linked to Miyoshi myopathy.