Primary lymphedema develops due to inherited hypoplasia/dysplasia or dysfunction of lymphatic vessels because of some intrinsic factors such as genetic mutations in the signaling pathway for vascular endothelial growth factor C (VEGF-C), while secondary lymphedema is caused by a dysfunction of the lymphatic vascular system due to trauma or parasitic infection [1,2,3]. This evidence concerns the gene VEGFC and primary lymphedema.