For minimal change disease (MCN) and focal segmental glomerulosclerosis (FSGS), urinary nephrin and podocin mRNA levels were lower in patients with MCN and FSGS compared to healthy controls, and urinary nephrin and podocin mRNA levels correlated with the degree of proteinuria within this context [33]. The gene discussed is NPHS1; the disease is focal segmental glomerulosclerosis.