Thus, since ApoE primarily binds to LDL-R and LDLR-related protein 1 (LRP1) in the brain, mediating the endocytosis and clearance of ApoE lipoproteins [66], the overexpression of LDL-R is an effective approach to significantly induce ApoE reduction and consequent alleviation of pathologic changes in AD mouse models [67,68,69]. This evidence concerns the gene APOE and Alzheimer disease.