BARHL2 and gastric cancer: Guo et al. conducted methylation detection using extracellular vesicles derived from gastric cancer cell lines, GC tissues, and gastric juice and found higher concentration of BarH-like 2 homeobox protein (BARHL2) methylation in gastric juice from patients with early stage of cancer and GC cell lines, with lower levels in gastritis (both normal and atrophis) [47].