With all these evidences, the Sca1-ETV6-RUNX1 model closely mimics human ETV6-RUNX1 preleukemic biology and therefore provides a means to evaluate the oncogenic potential of different environmental exposures that might play a role in B-ALL development, as is the case for common infections [19] or other environmental factors [52]. Here, RUNX1 is linked to precursor B-cell acute lymphoblastic leukemia.