Although the ETV6-RUNX1 oncogenic lesion can be frequently (>5%) found in otherwise healthy neonatal cord blood, only a few ETV6-RUNX1 carriers will develop B-ALL, as the ETV6-RUNX1+ leukemia rate is around 0.01% [11]. The gene discussed is RUNX1; the disease is precursor B-cell acute lymphoblastic leukemia.