RUNX1 and acute lymphoblastic leukemia: Since the ETV6-RUNX1 fusion gene is very specifically associated with an ALL of B cell phenotype, it has been a paradigm in the field, and many genetically engineered mouse models have been generated over the last decades, designed to express the ETV6-RUNX1 gene in a committed B-cell [45,46,47,48,49,50].