PIK3CA and rhabdomyosarcoma: PI3K binds to AR through the SH2 domain of p85α, activates PI3K to generate phosphatidyldiol-3,4,5-triphosphate (PIP3) and Akt, and phosphorylates downstream targets Bad and FKHR-L1 (fork head in rhabdomyosarcoma-L1) [36].