Accordingly, it is possible to underline that ADAR activity is an essential mechanism in mammals and altered editing has been associated with several human diseases, ranging from neurological and neurodegenerative diseases (schizophrenia, Alzheimer’s disease, depression, epilepsy, amyotrophic lateral sclerosis (ALS), and systemic lupus erythematosus (SLE)) to cancers and cardiovascular diseases [99,100]. This evidence concerns the gene ADAR and amyotrophic lateral sclerosis.