The Kots group [124] evaluated the associations of circulating levels of stable metabolites of nitric oxide, nitrate, nitrite (NOx), and endothelin-1, as well as the endothelin-1/NOx ratio, with blood pressure in 177 asymptomatic subjects without signs of coronary atherosclerosis, and in 457 patients with the presence of coronary lesions and suspected to have coronary heart disease with or without coronary lesions confirmed by coronary angiography. Here, EDN1 is linked to coronary atherosclerosis.