APOE and Alzheimer disease: Significantly higher levels of ecto-apoER2 were detected in AD APOE ε3/ε3 subjects compared to APOE ε4/ε4 samples (28% decrease, p = 0.019), whereas in the comparison with APOE ε3/ε4 subjects, the trend was maintained but significance was not achieved (19% decrease, p= 0.073) (Figure 4C).