Regarding the comparison between CSF samples subgrouped by APOE genotype, the changes in reelin species immunoreactive to the N-terminal antibody were maintained when comparing APOE ε3/ε3 AD cases (420 kDa decrease: 74%, p = 0.015; 310 kDa increase: 200%; p < 0.001) with NDC ε3/ε3 subjects. This evidence concerns the gene RELN and Alzheimer disease.