Given the wide range of TG2 enzymatic and non-enzymatic functions and its ubiquitous distribution in tissues and cellular compartments, it is not surprising that TG2 has a role in the development of several human pathological conditions, such as cancer, neurodegenerative disorders, inflammatory and cardiovascular diseases, and autoimmune conditions [54,55,56]. This evidence concerns the gene TGM2 and Autoimmunity.