Compared to the healthy postnatal kidneys, expression of Notch2 is significantly higher in both PECs (p < 0.001) and podocytes (p < 0.001) of CNF kidneys, whereas it is much lower in FSGS kidneys in both cell populations (p < 0.001 for PECs; p = 0.002 for podocytes) (Figure 4H). Here, NOTCH2 is linked to focal segmental glomerulosclerosis.