However, the mRNA of this receptor is cleaved by IRE1α endonuclease, which promotes CHOP, at first, to exhibit pro-inflammatory properties by repressing the expression of three essential genes: (1) the adiponectin gene, (2) the Eotaxin gene and the IL-13 gene, producing peripheral insulin resistance, decreased IL-4 production and decreased IL-13 signalling, favouring macrophage polarisation to M1 [89,90]. This evidence concerns the gene IL13 and Insulin resistance.