These facts open new avenues in the relationship between the gut microbiota disturbances in obesity and the initial triggers in keratinocytes activation like Adypokines, IL-6 and TNF-α from the sick adipose tissue and the LPS pass from a leaky gut due to advanced dysbiosis, and finally, innovative therapeutic approach in psoriasis [63]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.