For example, in human papillomavirus-positive cervical cancer cells, which show abnormal localization of HP1γ to the cytoplasm, inhibition of HP1γ translocation to the cytoplasm results in decreased expression of UBE2L3, which is involved in p53 degradation, resulting in altered transcription of p53 target genes [27]. Here, UBE2L3 is linked to cervical carcinoma.