Considering that HMGB1 and BRG1 can act together on the PI3K/Akt/mTOR pathway in cell experiments, this study further verified in the animal model, found that the use of glycyrrhizic acid affects the expression of the PI3K/Akt/mTOR pathway, which is consistent with the trend in the EMT model in vitro, indicating that glycyrrhizic acid may inhibit the process of EMT in pulmonary fibrosis through the PI3K/Akt/mTOR pathway. Here, HMGB1 is linked to pulmonary fibrosis.