IFNA17 and psoriasis: Additionally, the pathogenesis of psoriasis follows two more mechanisms: plasmacytoid dendritic cell (pDC) activation via Toll-like receptors (TLRs) and interferon-α (INF-α) release [15,16,17], which confirms the complex and complicated mechanism of this disease development (Figure 1).Thus, the NETs are found at each stage of psoriasis development, where they are engaged in an immune response manifested by T-cell imbalance, keratinocyte hyperproliferation, and the formation of autoantigens [18,19] (Figure 1).