In our study, a statistically significant effect of local treatment Cal/BD measured by a decrease in the immunofluorescent surface area of specific TRM markers was observed only in the 12th week of therapy (CD8, CD103, CXCR6, IL-17A, IL22), and in the 4th week of treatment, only CD69 and CD4 decreased. The gene discussed is ITGAE; the disease is Behcet disease.