MSH2 and malignant colon neoplasm: In the last years, it has been observed that HCPS, such as BC and OC, endometrial, gastric and colon cancers, are also associated with other genes such as PALB2, MLH1, MSH2, PMS1, PMS2, MSH6, TP53, CDH1, SKT11 and PTEN [4].