Of the 17 P/LP variants detected by the NGS panel testing (Table 1), ten fulfilled AIOM criteria 1 (58.8%), four fulfilled criteria 3 (23.5%), one did not fulfil criteria (PALB2:c.1451T>A) and two patients were not affected by tumours described by AIOM, and thus were included considering other specific criteria, including one LFS and one colon cancer (11.7%, Figure 5C). This evidence concerns the gene PALB2 and colonic neoplasm.