Except for the PVs in ATM (c.9023G>A) found in the PC patient, TP53 (c.645del) in the patient affected by LFS, MSH2 (c.1204del) in the patient with colon cancer and BRCA1 (c.181C>T) in the OC patient, all the remaining PVs were found in the BC patients (n = 13). The gene discussed is TP53; the disease is pachyonychia congenita.