Combining the mutation data with the TMB expression profile, we revealed that the TMB values of ccRCC patients were significantly associated with several gene mutations, including VHL, PBRM1, TTN, SETD2, BAP1, MTOR, HMCN1, CSMD3, and SYNE1 (Figure 3B). The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.