Combining the mutation data with the TMB expression profile, we revealed that the TMB values of ccRCC patients were significantly associated with several gene mutations, including VHL, PBRM1, TTN, SETD2, BAP1, MTOR, HMCN1, CSMD3, and SYNE1 (Figure 3B). Here, VHL is linked to nonpapillary renal cell carcinoma.