The protein product of DLAT, dihydrolipoamide acetyltransferase, accepts the acetyl group formed by the oxidative decarboxylation of pyruvate and transfers it to coenzyme A. Studies have reported that it is closely related to the pathogenesis of primary biliary cirrhosis (PBC), an autoimmune liver disease [73]. The gene discussed is DLAT; the disease is primary biliary cholangitis.