HSPA8 and coronary artery disorder: In that study, patients who were carriers of the rs2236659 G allele, which is defined as the minor allele in our study, had a decreased risk of coronary heart disease, and the rs2236659 G allele was associated with a 37–40% increase in luciferase expression by the reporter HSPA8 gene luciferase in endothelial cells compared with that in those with the A allele.