HSPA8 and Hepatic fibrosis: To clarify the profile associated with significant arteriosclerosis (Max-IMT ≥ 1.5 mm) and to evaluate the impact of the HSPA8 genotype on significant arteriosclerosis, a decision-tree algorithm was generated using four variables (HSPA8 genotype, age, sex, and hepatic fibrosis) (Figure 5).