ESR2 and Menkes disease: Some of the pGenes are associated with processes related to MD pathogenesis, such as TLR4, involved in immune response [33], ESR2, a regulator of estrogen response [34], TCF4, with a role in nervous system development [35], DCC, in charge of axon guidance and neuronal connectivity [36], PAX5, which interferes in mouse neural stem cells proliferation and migration [37,38], and CYP7B1, that participates in the metabolism of the neurosteroids DHEA and pregnenolone [39].