BCL2 and acute lymphoblastic leukemia: Furthermore, the hsa-mir-15/16 family is responsible for an insufficient response to chemotherapy and shorter survival [69], a poor prognosis [70], and it is correlated with BCL2 expression, which leads to apoptosis resistance [64]; hsa-mir-410 was previously shown to have a key role in proliferation, colony formation and the apoptosis of ALL cancerous cells [71], and the hsa-let-7 family is known as tumor suppressor miRNAs influencing chemosensitivity [72,73].