These approaches have highlighted that pigmentation genes as TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP, ATRN, involved in activation of the Hedgehog (HH) pathway, were identified as susceptible loci for BCC and SCC, independently of the pigmentation phenotypes [66,67]. Here, POMC is linked to skin basal cell carcinoma.