Similarly, the rs1999930 gene variant near the collagen matrix protein-coding genes COL10A1 (coding for α chain of type X collagen) and FRK (coding for fyn-related kinase) have also been associated with increased AMD risk [48], as they have copy number variants in the EFEMP1 gene coding for fibulin 3, a matrix glycoprotein [197]. This evidence concerns the gene EFEMP1 and age-related macular degeneration.