SHCBP1 and neoplasm: Shcbp1 is an Src homolog and collagen homolog (Shc) SH2-domain binding protein; its overproduction was shown to promote tumor (including breast) cell proliferation, migration, and invasion through multiple signaling pathways such as the cyclin-dependent kinase signaling pathway and the TGF-ß1/Smad signaling pathway [25,26,27,28,29,30,31,32,33,34,35,36,37].