Finally, we concentrated on the six common SNPs in four genomic regions reported to be associated with lung cancer risk in GWAS of European subjects: rs2036534 and rs1051730 at 15q25.1 [42,43,44,45] (CHRNA5–CHRNA3–CHRNB4), rs2736100 and rs401681 at locus 5p15.33 [31,46] (TERT/CLPTM1L), rs6489769 [47] at 12p13.3 (RAD52), and rs1333040 at 9p21.3 [48] (CDKN2A/CDKN2B). This evidence concerns the gene CHRNA5 and lung cancer.