Figure 21 shows the relation between the two pathways, and the differential regulation in RA CD8+ Temra cells that may cause increased mtorc1 activity. The effect of mTOR signalling on glycolysis is mediated by HIF1A and MYC upregulation [27]. The activation of mTOR was demonstrated in the CD8+ T cells of RA patients [42]. This evidence concerns the gene HIF1A and rheumatoid arthritis.