TP53 and cancer: BE-enriched cell cycle regulators included CSNK2A1 and UHMK1 (Table S6b), which are known to be upregulated in a number of cancers [36,37], as well as upstream mediators of p53-mediated apoptosis in response to the genomic damage response, such as PRKCD and CSNK2A1 [33] (Figure 4).