In order to verify reliable GRSDMs, 22 specific DNA methylation genes related to prognosis obtained in the training set were verified on 11 sets of GEO data, and 8 of the specific DNA methylation genes (DGRK, F2RL3, GRK5, NECAB2, OR1C1, OR2L13, OR6F1, and PIK3R6) had been verified in pan-cancer. Here, GRK5 is linked to cancer.