(4) The drug ibrutinib is a kinase inhibitor that decreases the B-cell proliferation and survival by irreversibly blocking the BTK B-cell receptor pathway and was reported to treat COVID-19 hyperinflammation [68]; and (5) montelukast is a cysteinyl leukotriene receptor antagonist with an anti-inflammatory effect, cytokine production reduction, and oxidative stress suppression [69]. Here, BTK is linked to COVID-19.