Our observations of interactions among changes in obesity genes, apolipoproteins, and ANGPTL3 are corroborated by findings from our earlier studies as indicated below: We have earlier demonstrated that the popular obesity gene FTO variant regulates obesity traits through interaction between carrier genotypes and measures of Apo’s and ghrelin [29]. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.