APOB and metabolic disease: Relationships between HDL and apolipoproteins in determining the risk or severity of metabolic disorders have been discussed in the literature, for example, Richardon et al., by way of performing a study implemented through multivariable Mendelian randomization simultaneously that accounts for genetic associations with lipids and apolipoproteins, observe that changes in cholesterol or triglycerides that are not accompanied by commensurate changes in apolipoprotein B may not lead to altered risks of coronary heart disease [28].