TREX1 and snowflake vitreoretinal degeneration: Although the genotype-phenotype correlation for AGS1 (OMIM #225750), FCL (OMIM #610448), SLE (OMIM #152700), and RVCL (OMIM #192315) has been experimentally established [26,27,28,29,30], the association between TREX1 genotypes and early-onset cerebrovascular disease, owing to SVD and CADASIL-like neuroradiological pattern, lacks systematic functional characterization via an in vitro heterodimers-based strategy [35].