To date, there are no studies to explain the relationship between the PNP gene and diabetes, but it is known that antagonists of CCR1 (C-C chemokine receptor type 1) can inhibit the recruitment of monocytes and lymphocytes into the renal interstitium and thus have a beneficial effect in slowing down the development of diabetic nephropathy [110]. The gene discussed is CCR1; the disease is diabetic kidney disease.