It was revealed that TP63 (transformation-related protein 63), VHL (von Hippel-Lindau tumor suppressor, LEF1 (Lymphoid enhancer-binding factor 1), RUNX3 (Runt-related transcription factor 3), ESR1 (Estrogen receptor 1), EGR1 (Early growth response protein 1) and AR (Androgen receptor) possibly played significant roles in NSCLC. This evidence concerns the gene ESR1 and non-small cell lung carcinoma.