Even though TBCD was suggested to be related to early-onset progressive encephalopathy with brain atrophy and thin corpus callosum [49], a missense variant in TUBA1A, the gene encoding the α1a-tubulin, has been previously reported in a patient who had an extremely thin cerebral parenchyma resembling hydranencephaly. The gene discussed is TUBA1A; the disease is Brain atrophy.