Extended testing for all the above-mentioned traditional and less commonly mentioned risk factors might help in a more precise stratifying of CVD risk in FH patients, and a result, more adequate individual management decision making and population-level resource allocation to help identify patients of high atherosclerotic risk, allowing cost-effective use of novel lipid-lowering agents including PCSK9 inhibitors, to assure a longer and disease-free life for patients with FH. This evidence concerns the gene PCSK9 and familial hyperaldosteronism.