Consistent with previous work for some non-coding strand G4s [22,30,37,46], we observed a significant, dose-dependent repression of CARD11 mRNA levels in both ABC DLBCL cells, RIVA and HBL1, and the GCB DLBCL cell HT following NSC373981 treatment (Figure 2D). The gene discussed is CARD11; the disease is diffuse large B-cell lymphoma.