CHUK and cervical carcinoma: Furthermore, the adverse negative regulation of the NF-κB and Akt pathway is observed pointedly in the combination mode of treatment, and the phosphorylation pattern of Akt by each standalone treatment and their combination was similar to that of IKK-α; these all confer that these actions may be at least partly through the suppression of the IκB degradation and phosphorylation in PTX-resistant cervical cancer cells [57].