Three specific recurrent non-truncating NF1 hotspots (residues p.Met1149, p.Arg1276, and p.Lys1423) have been linked with Noonan-like features with specific phenotypes: p.Arg1276 and p.Lys1423 pathogenic missense variants were associated with a high prevalence of cardiovascular abnormalities, including pulmonic stenosis; additionally, p.Arg1276 had a high prevalence of symptomatic spinal neurofibromas; p.Met1149 positive cause a mild phenotype, characterized mainly by pigmentary manifestations [34]. Here, NF1 is linked to Pulmonic stenosis.