NF1 and malignant adrenal gland pheochromocytoma: Moreover, three patients of G5 clinical group showed malignant pheochromocytoma/paragangliomas associated to NF1 and carried three different nonsense mutations (p.Arg1276*, p.Trp1641*, and p.Asn2364*) in the NF1, distributed in different protein domains (Figure 1A).