It is intriguing that the p.Arg1276* mutation was associated to cancer development (our study and ref. [77]) and cardiovascular abnormalities (our study in NF_10, 11, and ref. [34]); possibly a different genetic background (e.g., variants in NF1-related genes) or non-genetic factors (e.g., environment, exposure to chemicals and hazardous substances, etc.)may explain the diverse clinical manifestations. Here, NF1 is linked to cancer.